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Contraindicated (1)pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with strong CYP3A4 inducers; these drugs decrease exposure to vandetanib by nearly forty%.pentobarbital will lessen the level or effect of glecaprevir/pibrentasvir by affecting he